Accurate Nanoparticle Characterization

In the past accurate analysis of wear particles has been limited by problems associated with particle isolation, distribution, and display. For example, an inefficient and/or incomplete digestion of the proteinaceous content can lead to agglomeration or loss of particles. Furthermore, separation of  particles from digested solution through filtration or embedding into resins can be an additional source of agglomeration and loss. Moreover particles of small dimension (few nanometers) can easily bind to proteins, stick to the wall of tubes or flushed away through the pores of filters.
Agglomeration, loss, unwanted residues affect the quality and clarity of particle imaging with obvious repercussions on the reliability and reproducibility of the morphological analysis.
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